Newcastle take on Leeds on Sunday for the first time in the league for more than a decade.
Leicester City are not doing to well with their title defence, but it is a different story in the Champions League.
Tottenham Hotspur host rivals West Ham United at White Hart Lane on Saturday.
Antonio Conte has backed the policy at Chelsea under which players receive a bonus only if they claim trophies rather than win individual league or cup fixtures or qualify for Europe.
The last visit to Old Trafford left Arsène Wenger stern faced, forced to admit to feeling like a “bitter loser” as he strained to summon an explanation for a deep disappointment.
Burnley are playing in the Premier League this season, while Queens Park Rangers are in the Championship.
Mark Lawrenson has suggested that Liverpool will beat Southampton 2-1 this afternoon.
Aston Villa boss Jack Grealish has raved about Jack Grealish's display against Brighton.
Tottenham Hotspur are fifth in the Premier League, but are stuttering in the Champions League.
Could David Gold and David Sullivan sell West Ham United like they sold Birmingham City?