Brad Guzan had a disappointing night for Middlesbrough as they exited the EFL Cup.
Reports suggest that both players will be joining the Bundesliga club before the weekend.
Manquillo returned to the Premier League by signing for Sunderland on a season-long loan deal.
The Everton striker drew a blank against Yeovil Town this week.
Wolves go into the game against Huddersfield knowing another victory will keep them well in the hunt for a promotion place on the weekend.
The US international's departure to Newcastle United has opened up doors for other Tottenham players.
He's attracting attention from a host of Premier League clubs but who is Nottingham Forest's teenage sensation Oliver Burke?
The 27-year-old striker and former Reading midfielder will both miss Saturday's clash with Bristol City along with left-back Joe Bennett.
Aleksandar Mitrovic and Dwight Gayle picked up head injuries in the EFL Cup and will now have to sit out the crucial Championship match.
The Black Cats boss has come in for criticism after suggesting they will be in a relegation battle this season.
The New York Red Bulls forward and Columbus Crew SC striker headline our Week 13 line-up after both hitting hat-tricks.
This is more than just an impressive start to the season.
Daniel Sturridge trained with the rest of the England squad at London Colney on Monday as he attempts to prove his fitness for Euro 2016 after a recent calf injury.