United and City clash in what might just be the biggest Manchester derby ever on Saturday with neither blue nor red wanting to give up the incentive early on.
Rangers take on Celtic at Parkhead in the first Old Firm derby in the Scottish Premiership in four years.
Lascelles was dropped from Rafael Benitez's side for the victory over Reading last month.
The Tottenham Hotspur-owned Schalke midfielder played against Bayern Munich in the Bundesliga on Friday evening.
West Ham host Watford in the Premier League this afternoon.
Philippe Senderos is reportedly set to start for Rangers against Celtic today.
Another teenager could be edging closer to his Tottenham debut after Pochettino's latest comments.
The German is confident ahead of the West Yorkshire derby.
Zaza is expected to make his Hammers debut against Watford on Saturday.
Alex McLeish has been in charge of Birmingham City, Aston Villa and Rangers.