The Belgian's absence against the German side demonstrated his importance to the Lilywhites.
Garry Monk made 11 signings during the summer after taking over at the Whites, but which ones have been the best?
The club record signing is in the squad for the match at Inter and could make his long-awaited Saints bow.
Burton Albion boss Nigel Clough has been speaking in glowing terms about his veteran winger Lloyd Dyer's impact on the team.
Former West Bromwich Albion striker Peter Odemwingie may well be set to join League One side Bolton Wanderers.
Arsenal have made a strong start to this season, both domestically and in Europe.
Crystal Palace signed Christian Benteke from Liverpool in the summer.
Gayle scored his 11th goal in as many Championship games with a brace in the 2-0 win over Barnsley on Tuesday.
Sunderland are yet to win a Premier League match this season.
Birmingham City have loaned some real talents over the years, we take a look at some of the biggest loan stars to have graced St Andrew's in recent times.
Throughout the history of the Premier League there have been many great goalscorers, but these five take the honour of being known as the best of the best.
The Forest winger made a late-window switch to Ashton Gate.
The Denmark international has signed a two-year deal at Nottingham Forest in recent days.