The Belgian midfielder will miss the home game against Everton with a hamstring injury.
The Saints should have departed Italy with a comfortable win and Guardiola knows his side will be up against it this weekend.
The Old Firm rivals meet in the Scottish League Cup semi-final at Hampden Park on Sunday.
Just over two years ago Clark's departure from Birmingham City was a big turning point for the club.
Leeds United failed to win against Wigan Athletic in the Championship on Tuesday evening.
The Hull City captain is set to make his first appearance of the season against Stoke City this weekend, after helping his manager against Bournemouth.
It may seem strange that The Toffees are chasing a new centre-back due to their excellent defensive record, but Semedo is a talent that cannot be ignored.
Find out all you need to know as Jose Mourinho returns to Stamford Bridge with Manchester United.
Mark Warburton’s Glasgow Rangers will face Old Firm rivals Celtic in the Scottish League Cup semi-finals this weekend.
Cherries boss Eddie Howe has been speaking ahead of his side's Saturday lunchtime clash with Tottenham.
As weeks go, Christian Benteke’s has already been exceptional.
Arsène Wenger knows better than most how suddenly the negativity in modern football can grip. “It is a virus that travels very quickly and goes very slowly,” the Arsenal manager said. Few opponents have triggered it quite so readily in recent years as Swansea City and Wenger sees the visit of the Welsh club to the Emirates Stadium on Saturday afternoon as a defining moment for his team.
Bob Bradley was honest enough to admit “there will be sceptics” among the Swansea fanbase and beyond.