The striker has not played a senior game in 14 months.
Burnley's promotion push has been halted slightly with three draws in their last five games.
Lucas Joao has made 36 appearances in the Championship for Sheffield Wednesday this season.
Norwich City, Sunderland and Newcastle United are in the fight to stay up.
Skrtel has found it hard to re-establish himself in the side following a hamstring injury in December.
The Hoops were knocked out of the Scottish Cup by their Old Firm foes.
Leeds United and Wolverhampton Wanderers go head-to-head later this week.
Burnley face Middlesbrough in a top-of-the-table Championship clash this week.
Four youngsters will not be at Sunderland next season
Trevor Sinclair was impressed with Andros Townsend’s performance for Newcastle United against Swansea City at the weekend.