Van Dijk has been in impressive form this season for Southampton including in the weekend's 0-0 draw with Liverpool.
West Ham United defender Winston Reid is set to miss their next match, after picking up a red card at White Hart Lane.
Sunderland have won their last two games to move closer to survival.
Newcastle United have won their last nine matches in all competitions to move to the top of the Championship.
Wijnaldum featured for the whole 90 minutes as Liverpool were held to a 0-0 draw by Southampton.
Tottenham claimed a stunning 3-2 comeback win over West Ham as they returned to Premier League action in fine fashion.
Leeds' unbeaten run was brought to an end by the Championship leaders at Elland Road.
Birmingham City have reportedly offered a trial to Jordan Spence.
Liverpool striker Daniel Sturridge is struggling for game time this season.
Peterborough United midfielder Michael Bostwick's misplaced pass could serve as a warning to the likes of Liverpool, Bournemouth and Wolves.