Mark Noble and Andy Carroll are among those to miss out, but Diafra Sakho could return.
Former Celtic and Southampton midfielder Victor Wanyama was answering questions during a Tottenham Hotspur Q&A.
Liverpool could be without Adam Lallana and Philippe Coutinho for the trip to Southampton - meaning an opportunity is likely to open up for Daniel Sturridge.
Lee Cattermole is expected to be on the sidelines until March.
Everton host Swansea City at Goodison Park on Saturday.
The Magpies travel to what will be a sold-out Elland Road on Saturday.
Brighton & Hove Albion and Aston Villa will face each other in the Championship this evening.
The first Madrid derby of the season is on Saturday evening - here is how you can watch it all unfold.
Queens Park Rangers host Norwich City in Ian Holloway's second R's debut.
West Ham United will face Tottenham Hotspur in the Premier League this weekend.