The Dutch international is not injured but is not strong enough for the game.
Former Germany international Dietmar Hamann has voiced a concern for Tim Sherwood ahead of the FA Cup final.
Cheikhou Kouyate joined West Ham United from Anderlecht in the summer of 2014.
Southampton have a number of players who are currently ruled out through injury.
Crystal Palace midfielder James McArthur is expecting his side to test Manchester United at the weekend.
Manuel Neuer put in a superb performance in goal for Bayern Munich, despite the German champions suffering a heavy defeat to Barcelona.
Celtic manager Ronny Deila picks games against Inter Milan and Rangers as his favourite of the season.
The Newcastle icon was left disappointed again, however...
Arsenal, Chelsea, Manchester United and Aston Villa all feature when football meets politics.
Arsenal will host Swansea City at the Emirates Stadium in the Premier League on Monday.