The two defenders are both set to sit out Saturday's home game against Fulham, while Albert Adomah is also a doubt for the match.
Away from the Scottish League Cup semi-finals, Scottish Premiership action continues as normal.
Patrick van Aanholt and Lamine Kone are back in full training as the Black Cats prepare to face West Ham.
Mick McCarthy's options have been bolstered by a return to fitness for two of his most important attacking players.
Southampton lost their Europa League match against Inter Milan 1-0 in the San Siro.
The two goalkeepers are fighting it out for the Rangers number one spot.
Burnley take on Everton and Lukaku at Turf Moor this weekend.
The Dons face Greenock Morton at Hampden Park with a place in the Scottish League Cup Final at stake.
West Ham United host Sunderland in the Premier League this weekend.
Red, White and Blue 'Ragtime' the musical comes to London for a third time