Aston Villa face Swansea City in a match of vital importance at the weekend.
Newcastle assistant Simpson says that Sunderland will be favourites for the derby.
A white-hot atmosphere is expected at Anfield as Jurgen Klopp settles in for his first home game in charge of Liverpool on Thursday.
Celtic take on Molde in the Europa League on Thursday evening.
Sunderland are currently five points adrift of safety, and are still looking for their first win of the season.
The Spurs boss must utilise his squad more effectively this season.
Arsenal goalkeeper Petr Cech has a point to prove to former employers Chelsea this season, according to ex-England international Rob Green.
Leeds United owner Massimo Cellino has come under severe criticism in recent weeks.
Jamie Paterson is currently taking in a loan spell at Huddersfield Town from Nottingham Forest.
West Bromwich Albion have scored just seven times in their opening nine Premier League matches this season.