Jimmy Floyd Hasselbaink helped Queens Park Rangers keep a clean-sheet during his first match in the dugout.
The German has been in scintillating form for the Gunners this season.
Crystal Palace and Manchester City both recorded victories at the weekend.
The former Liverpool defender was more intimidated by Arsenal's old ground than their modern one.
Jose Semedo has made just 11 appearances for Sheffield Wednesday this season.
Lovren was stretchered off during the weekend's 2-2 draw with West Bromwich Albion.
The former Paris Saint-Germain midfielder has been exceptional for the Eagles this season.
The Owls have struggled when they have been away from Hillsborough this season.
Tottenham have been drawn with Fiorentina in the Europa League.
Mark Warburton's side are currently three points clear at the top of the table.