The former Chelsea midfielder, who has scored 12 goals in his last 15 MLS appearances, has been ruled out for three to four weeks with a calf strain.
The Magpies were beaten 2-0 at St James' Park on Saturday.
The Hammers, along with Chelsea and Manchester pair United and City, were present during the 21-year-old's most recent outing.
Tottenham loanee admitted the last few weeks have been difficult for him.
The Belgium international spent two years on loan at Atletico Madrid before becoming Chelsea's number one goalkeeper.
The Blues are currently second in the table after the first five games of the season.
Daryl Murphy is yet to make his Newcastle United debut after joining from Ipswich Town in the summer.
Pickford is currently Sunderland's regular goalkeeper following an injury sustained by Vito Mannone.
Leeds United host Blackburn Rovers in the EFL Cup.
Vincent Janssen is yet to score for Tottenham Hotspur since signing in the summer.
Gennady Golovkin did not waste his energy on anything other than banalities and formalities when he addressed the world’s media for a final time before Saturday night’s intriguing clash of weights and styles against Kell Brook. There was no need. Why use words to sell a fight when his fists have long performed that job with such distinction?
Ska legend Prince Buster, who created records such One Step Beyond and Madness, died on Thursday at the age of 78.