Tottenham's victory against Manchester City means Pochettino joins Manchester United, Arsenal and Liverpool managers with multiple wins against Guardiola.
The Toffees blew a one-goal lead to draw with Crystal Palace on Friday.
Sunderland picked up a 1-1 draw against West Bromwich Albion at the weekend.
Townsend replaces Manchester City winger Raheem Sterling who pulled out of the squad with injury.
The Hoops youngster will be looking to one day make the same kind of impact that his namesake has made so far this season.
Tottenham Hotspur supporters roared their approval of Mauricio Pochettino, during their 2-0 win against Manchester City.
Aston Villa are on the look out for a new manager, after parting company with Roberto Di Matteo.
Leeds United won 2-1 against Barnsley, to extend their winning run at Elland Road to four matches.
West Ham United could only pick up a 1-1 draw with Middlesbrough last weekend.
Celtic edged out Dundee, while Ibrox side Glasgow Rangers beat Partick Thistle.