Sky Bet have opened the new market in time for the new season, which begins two weeks on Saturday, and placed Newcastle's Rafa Benitez, Leicester's Claude Puel and Cardiff's Neil Warnock as 7/1 front runners.
Watford's Javi Gracia is next on the list at 8/1 and is the only other manager to occupy shorter odds than Manchester United's Jose Mourinho and Southampton's Mark Hughes - both 12/1.
Benitez is entering his third full season as Newcastle boss, but continues to work in more difficult circumstances than many of his contemporaries - much to the Spaniard's frustration.
Puel, meanwhile, was strongly rumoured to be leaving Leicester towards the end of last season, after a mixed start to his nine-month tenure.
And after being promoted against expectation last season, Cardiff are among the early favourites to be relegated this campaign, which perhaps explains Warnock's presence.
Whose boss will be first to go - Newcastle, Leicester or Cardiff's?