Spurs lost their first Premier League game of 2018 at the weekend against Manchester City, and have a season defining FA Cup semi-final on Saturday.
Some key players will likely be rested, while this is an opportunity for those on the fringes of the squad to stake their claims to start against United.
We are predicting a return for defender Toby Alderweireld, and a first Premier League start for new signing Davinson Sanchez.
Out would go Eric Dier, Erik Lamela, Kieran Trippier, Dele Alli, Mousa Dembele and Davinson Sanchez.
There is also a case to rest Harry Kane, Hugo Lloris and Christian Eriksen, but Tottenham must show a solid Brighton side the respect they deserve, and try and ensure a win to get back into good habits ahead of the crucial fixture with United.
This would be a big chance for Toby Alderweireld to get back into Spurs' plans and potentially secure a place on the bench after failing to make recent squads.
Ben Davies could even be rested too if Danny Rose is recovered from his calf strain, and Fernando Llorente should return to the Spurs bench.