The 24-year-old picked up a similar ankle injury last season but recovered relatively quickly.
Mauricio Pochettino has the international break to buffer the loss but Premier League legend Alan Shearer - the man whose record Kane is hunting down - has explained to Coral that the injury could actually benefit the North Londoners... and England.
"Son will now have the opportunity to be the leading man in the team and they will be looking for him to continue producing the goals," Shearer told Coral.
"He has been superb this season and one of their best players. If he keeps up his scoring record, they should be ok without Kane for a few weeks. From an England point of view, it could end up being a good thing."
Shearer explained that when he was at his peak and heading into Euro 96 he had to have a hernia operation at a similar point in the season.
And he says that short rest was just what he needed to go again and really hit the heights.
"I know you are working hard behind the scenes but you are not travelling, playing the games or getting kicked," Shearer added.
"I then went on to finish as the top goalscorer at the tournament. The general feeling is that the top players are playing too much football so at least he is going to have a break. He has had the same injury before so he will know how to handle it and so will the medical team."