The Wanderers will return to action in the Championship in a few hours’ time when they take on Reading at home.
Nuno’s side will head into the game at the Molineux Stadium on the back of a 4-1 defeat to Aston Villa away from home at Villa Park in the league.
Afobe did not start the match against Villa, but the striker came on as a substitute midway through the second half.
The 25-year-old has yet to make a start in the Championship for Wolves since his move from Premier League club Bournemouth in the January transfer window.
In 153 minutes of league football for the Wanderers, the former Arsenal prospect has scored one goal, according to WhoScored.
Afobe joined Bournemouth from Wolves in January 2016 for a transfer fee reported by BBC Sport to be worth £10 million.
Wolves fans on Twitter have urged manager Nuno to include Afobe in the starting against Reading this evening.
They will.— Kate Wright (@Wrightgal80) March 13, 2018
3 changes i'd make tonight.— Jay (@Wolvesjay90) March 13, 2018
Batth, Bonatini, Jota out. Bennett, Afobe and Costa in.
It is must win #wwfc
Ive been a big fan of giving Leo time to find his form but tonight he needs dropping for Afobe or Cav Jota Costa front 3 #wwfc— Ryan Wall (@Ryanonawall2) March 13, 2018
Simple changes tomorrow. Leo out batth out. Bennett and afobe in. Possibility of a saiss recall or Costa too imo. #wwfc— AnotherReject (@dan_jeavons) March 12, 2018
I’d give Afobe a start tomorrow but I reckon it’ll be Costa that comes in for Leo #wwfc— Jason (@JasonJ1987) March 12, 2018
Tomorrow night, I’d easily change Batth out for Bennett in, I’d also look to switch Leo & Afobe #WWFC— Westwood (@nathanwesty) March 12, 2018
Two changes for me tomorrow would be Bennett for Batth (still don’t understand why he was dropped for Leeds) and Afobe for Bonatini. #wwfc— Sam Green (@Greener099Sam) March 12, 2018