Kane damaged his ankle against Bournemouth at the weekend, and faces a spell on the sidelines.
As yet, it is not clear just how long Kane will be on the treatment table for, as he faces scans to detect the seriousness of the issue.
However, Llorente is set to be overlooked, with Heung-Min Son to become Tottenham’s new main striker.
Llorente was brought to Spurs to be their main back-up to Kane, but he has struggled badly this season.
And Pochetttino’s latest decision to overlook the Spaniard is set to lead to his exit at the end of the campaign.
With Son brought in up-front, Lamela will take Son’s slot just behind the striker.
Lamela has started just seven matches all season, but will be brought back into Pochettino’s first team for Tottenham’s next match, which comes against Swansea City in the FA Cup.