Tottenham striker faces a spell on the sidelines.
Kane was substituted in the first half of Tottenham's 4-1 win over Bournemouth.
One set of fans with zero sympathy for Kane's injury are Newcastle United supporters.
Lejeune subsequently hit out at Kane for failing to apologise.
He told The Independent in November, three months after the injury: "At first, I was angry. We all make mistakes, we all commit fouls but I think an apology would have been good, especially from such a great player, the England captain, but I have never received one."
Now Kane is out, and his injury is not the fault of any player, coming in an innocuous collision with goalkeeper Asmir Begovic as opposed to a bad tackle.
England's long-shot World Cup chances may hinge on Harry Kane being fit for this June's tournament.
But there is little sympathy on Tyneside for his plight.
Here is a look at how Newcastle fans reacted to his injury.
Now Kane will hopefully know what Florian Lejeune went through when he scythed through him at st James park and, put him on the sick for months!— boilerman (@Russcarter7) March 11, 2018
Wonder what Florian Lejeune made of that tackle on Kane? Karma at work there. Bet he won’t be out as long as Lejeune was though #bbcfootball— Chancel MyMbembaship (@mymbembaship) March 11, 2018
Remember when Kane injured Lejeune on Lejeunes Premier League debut for us. Dont remember him showing any sympathy towards Lejeune— Leroy (@LeroyNUFC) March 11, 2018