The Primeira league leaders have plenty of talented players in their squad.
Jurgen Klopp's side are favourites to overcome the 2004 winners of the competition but Sergio Conceicao's men, who are unbeaten in the league, will certainly cause Liverpool plenty of problems.
Here are three Porto players the Merseysider's need to be wary of to help ensure their passage to the quarter-finals:
Vincent Aboubakar has been a revelation for Porto since returning from a loan spell at Besiktas last summer. The Cameroon international has scored 26 goals this season, five of them in the Champions League. Aboubakar is a huge physical presence and is a real handful as well as being a clinical finisher.
Hector Herrera is the engine in Porto's midfield and is the most complete midfield player in their squad who often makes the whole team tick. He has the ability to break up play as well as create and even score the odd goal. The 27-year-old has 63 caps for Mexico and is the club captain.
Malian striker Moussa Marega is having the best season of his career. He has scored 15 goals for Porto so far this season and is full of confidence at the moment. Marega is another strong, powerful striker who stands at six foot tall and he will certainly be a handful for both Liverpool centre-halves.