Aubameyang is likely to start for the Gunners, having joined Arsene Wenger's side from Borussia Dortmund in the January transfer window for a fee reported by The Guardian to be worth £56 million.
Alderweireld could also feature in the North London derby on Saturday afternoon as well, having recovered from a hamstring injury.
The Belgium international defender, who earns £50,000 per week at Tottenham according to The Guardian, is aware of the danger posed by 28-year-old Gabon international striker Aubameyang.
"He's very quick, he's a good finisher, he has it all,” Alderweireld told Sky Sports about Aubameyang.
"He is in a good moment now as well so it's going to be very difficult to beat him but I think we will be ready for it.
"You have to work your mind. One against one, on the same line, he will beat you, so you have to be very clever, you have to read the situation and try to beat him with your head."
The Pierre-Emerick Aubameyang factor
Aubameyang is one of the best strikers in the world, and the pace of the former Dortmund star is going to be an issue for Spurs.
The former AC Milan prospect loves to run at defenders, and the pacy striker will be determined to score a goal or two at Wembley.
The 28-year-old scored on his debut for Arsenal in the 5-1 hammering of Everton at the Emirates Stadium in the Premier League last weekend.