Even as the Toffees faltered early in the season, Gareth Southgate appeared willing to stick with a still improving player in the national team.
But Keane's hold on that spot is slipping with every passing week and he must now be wondering if the switch to Goodison Park was the right idea after all.
The former Manchester United defender was awful in a three-man defence - Southgate's preferred system - against Arsenal at the weekend, as were Ashley Williams and Eliaquim Mangala.
When Everton manager Sam Allardyce then switched to a back four for the second half, trailing 4-0, Keane was the man to make way.
He no longer appears to be guaranteed a place at Everton - at least as long as he underperforms - and he must be looking enviously at Burnley, where a settled side in a well-drilled system are delivering on a weekly basis.
James Tarkowski - Keane's Burnley heir - could well find himself in the England reckoning in the coming weeks, while Newcastle United captain Jamaal Lascelles has also been tipped for a call-up.
There is great competition for places in the England defence, meaning Keane is going to have to earn his selection for this summer's World Cup.
Keane may well go on to enjoy a fruitful career on Merseyside, but right now it looks as though his decision to disrupt his development with a move away from Burnley could cost him.