Merson is tipping West Ham United for defeat.
Merson believes that tactically he believes West Ham are poorly matched against the Terriers.
He explained: "The Terriers are strong at home, though, and I'm not sure whether West Ham will be able to cope with their pressing game. With that in mind, I fancy David Wagner's men to get another huge three points for their survival bid."
Huddersfield are in 11th place in the Premier League table, with West Ham in 15th, but only two points separate the two teams.
This game is an important match for both sides accordingly, in their aim to move clear of the relegation scrap and target the top 10.
It is the first time managers David Moyes and David Wagner have met.
When the two teams clashed earlier in the season, West Ham came out on top at the London Stadium, with the 2-0 win giving a much needed victory to then manager Slaven Bilic.