Tottenham travel to Wales on Tuesday night to face Swansea City.
The 25-year-old has returned to full fitness after a double-hip injury had kept the Argentina international sidelined since October 2016, and has since made seven Premier League appearances.
However, only of those has been from the off in a 2-0 win over Brighton, with the likes of Christian Eriksen, Dele Alli and Son Heung-Min keeping the former Roma attacker out of the starting eleven.
However, with so many games being played and rotation likely to be needed as the north Londoners go up against West Ham United in two days' time, Lamela could be afforded his second start of the season.
Lamela has managed just 157 minutes of Premier League action this season in total, but his pace and trickery could be the quality required to unlock a Swansea defence who will in buoyant mood after beating Watford last time out.
No meltdowns tomorrow when the team is announced. Expect full use of the squad. Expect Llorente, Lamela, Winks, Trippier and Davies to start. Be very surprised to see Kane in the 11.— JaiP (@JaiP72) January 1, 2018
Lamela, Davies and a Trippier will start imo— Ben (@THFCBenn) January 1, 2018
Shouldn't need him I would put sonny up top and start lamela— Michael Muckian (@MuckianMichael) January 1, 2018
Rest Eriksen for the Swansea game and put Lamela in— Jamie (@EliteBale11) December 30, 2017
Predicting the spurs DGW line ups— fᏢᏞ fᏒᎪuᎠ (@FplFraud) December 31, 2017
Lloris aurier vert Sanchez Davies
Lamela alli Eriksen
Vs west ham
Lloris aurier vert Sanchez rose
Son alli Eriksen