The Cypriot champions travel to London to face Spurs in both sides' final Group H game in the Champions League. APOEL have it all to play for, as they can still finish third with a surprise result against Spurs.
Both Borussia Dortmund and APOEL sit on two points in Group H with one game to play, but Dortmund are ahead on the head-to-head rules. That means Donis' side must better Dortmund's result against Real Madrid on Wednesday evening.
They could have a chance, as Mauricio Pochettino is set to rest a number of his first-team stars and that could see the likes of Kane dropped to the bench. Donis believes the 24-year-old Spurs ace can "change the dynamic of the game."
“I have seen Tottenham's squad. Even if they make changes, it will not alter their style of play,” Donis said. "If Kane remains on the bench then that could change the dynamic of the game. He is a player who is scoring with ease.
“What I am interested to see is if they start with three at the back or four. The fact we are at the final matchday of the group phase and still competing for third place is very important.”
Spurs could well rest Kane as they look to get back to winning ways following a poor run of form in the Premier League, which has seen them win just two points from a possible 12 after losses to Arsenal and Leicester and draws against West Brom and Watford.
They play host to Stoke City on Saturday afternoon at Wembley, with three points enough to leapfrog north London neighbours Arsenal if the Gunners lose to Southampton on Sunday.