Everton head into the game having endured a miserable last week, first falling to a 5-1 defeat at the hands of Atalanta in the Europa League.
The Toffees were then thumped 4-1 at Southampton on Sunday afternoon, with caretaker David Unsworth finding similar defensive problems to predecessor Ronald Koeman.
Over a month on from Koeman's exit, Everton are still searching for a new manager, and they appear to be closing in on the appointment of former West Ham boss Sam Allardyce – but not in time for tonight's game.
Meanwhile, opponents West Ham drew 1-1 at home with Leicester City on Friday night, turning in a strong second half showing but failing to find the winner at the London Stadium.
After opening with a 2-0 defeat at Watford, new West Ham boss David Moyes is now back on the road tonight, returning to face the club he left back in the summer of 2013.
Moyes will be hoping for a first win, and pundit Mark Lawrenson has predicted that he will get just that with a 1-0 victory at Goodison Park.
Lawrenson has told BBC Sport that he thinks Everton are 'all over the place', and West Ham will subsequently pick up a surprise 1-0 win, which would be their first Premier League away win this season.
“Everton capitulated again against Southampton on Sunday and it is difficult to see them getting a new manager in time for this game, even though it is more than five weeks since Ronald Koeman was sacked,” said Lawrenson. “The Toffees are still struggling to score goals but it is at the back where they have the biggest problems. They are all over the place.”
“They have conceded at least two goals in each of their seven games under caretaker boss David Unsworth, and have shipped 11 goals in their past three matches. Even West Ham's defence is not that bad,” he added.