Sunderland will take on Millwall at the Stadium of Light in the Championship on Saturday afternoon.
Prutton has backed the visiting team to pick up all three points from the encounter courtesy of a narrow 1-0 win.
“It's becoming more and more apparent that Sunderland didn't have a plan in place when they sacked Simon Grayson, and it looks like they've wasted the opportunity of an entire international break to get someone in place,” Prutton wrote on Skysports.com.
“Millwall are winless on the road this season and it's the kind of game you have to win at home if you want to survive in the Championship. But I fancy Neil Harris' men to pile more misery on the Black Cats.”
A footnote added: “Prutton predicts: 0-1.”
Sunderland are in a horrible run of form at the moment and are in danger of going down to League One at the end of the season.
The Black Cats, who are without a permanent manager at the moment, are currently at the foot of the standings with just 10 points from 16 matches.
Millwall will fancy their chances of picking up all three points at the Stadium of Light, but perhaps the home team could bag a win if they score an early goal and then defend deep.