Dembele has been out of action since September due to an ankle problem, but Pochettino has suggested that the 30-year-old midfielder is close to full recovery.
Spurs will face Bournemouth at the Wembley Stadium in London in the Premier League on Saturday afternoon.
Tottenham will then face Madrid away from home at the Santiago Bernabeu in Champions League Group H on Tuesday evening.
Pochettino’s side will take on Liverpool at home in the league next weekend.
“Maybe next week yes, if all is going well like today,” Pochettino told Football.London when asked if Dembele will be back next week. “Maybe next week, Real Madrid he can be involved or Liverpool. We hope he can be available again.”
Dembele is one of the best players in the Premier League and is a key figure in the current Tottenham team.
Although Spurs have done well in the absence of the 30-year-old, the return of the former AZ star is only going to enhance Spurs’ chances of winning against Madrid and Liverpool.