Jose Mourinho and Jurgen Klopp argue on the touchline during the Premier League match between Manchester United and Liverpool.
The Premier League returns this weekend after the international break and things don't get much bigger than the lunchtime kickoff on Saturday (October 14) as Liverpool host Manchester United.
The two great rivals are among the division's so-called 'top six', although have had varied starts to the new season with United undefeated and only off top spot on goal difference, while the Reds are seven points behind in seventh.
Here are three key battles to watch out for during the clash at Anfield.
Liverpool player Mohamed Salah in action during the Premier League match against Newcastle United.
Mohamed Salah against whoever plays left-back
With it confirmed by the club Sadio Mane faces up to six weeks on the sidelines with a hamstring injury, there will be more emphasis on his fellow winger Salah to perform having already scored four league goals and provided two assists this term.
On the right flank the Egyptian could arguably be targeting the Red Devils' weakest area in left-back, with converted winger Ashley Young having played there the last three league games but Matteo Darmian and Daley Blind also used at times.
Manchester United's Romelu Lukaku celebrates scoring the team's fourth goal during the English Premier League football match against Crystal Palace.
Romelu Lukaku against Liverpool centre-backs
Since his summer move from Everton, Lukaku has only failed to score in one of his ten appearances for Jose Mourinho's side and has 11 goals in total.
The Belgian is the division's topscorer and will be facing a heavily criticised central defence that has let in 12 already this term. Only Crystal Palace and West Ham United have a worse record.
Philippe Coutinho against Nemanja Matic
Now that the speculation about Coutinho joining Barcelona has died down, for the time-being at least, the Brazilian has been able to concentrate on football and has been excellent since his return from injury.
With Mane out the 25-year-old is the main source of creativity for manager Jurgen Klopp, but the equally impressive Matic will be making it his mission to suppress the attacking midfielder and maintain Man United's record of just two goals conceded in the top flight thus far.