Trump and GOP Sen. Bob Corker get into a Twitter flame war

Donald Trump Looking Concerned

Trump said that he declined to to endorse Corker's re-election campaign or consider Corker for Secretary of State.

Tennessee Republican Bob Corker broke party ranks once again over the weekend, as tensions escalated on social media between the senator and President Donald Trump.

In a series of tweets, Trump said that he declined to endorse Corker's re-election campaign or consider Corker for Secretary of State, blaming him for "the horrendous Iran Deal." Corker announced last month that he would not seek re-election because he wanted to be able to perform his public service thoughtfully and independently for the remainder of his term.

Corker blasted the White House in response, tweeting that it had become an "adult day care center" and deriding that someone "missed their shift."

Corker, like Trump, has roots as an entrepreneur in the construction and real estate industry, and is chair of the Senate Foreign Relations Committee, and a member of the Banking Committee and the Budget Committee.

Corker publicly slammed an version of Obama-era nuclear agreement in 2015. But reports from outlets like Politico indicated that as a top-ranking senator in the foreign relations committee, Corker was involved in a complex and delicate set of negotiations with Democrats.

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Corker and Trump have locked horns before. Corker was among those who criticized Trump after his response to a white nationalist rally in Virginia earlier this year. (Trump called Corker's criticisms " strange .")

The latest exchange between Trump and Corker comes as Congress faces the behemoth task of tax reform. Corker said he cannot support tax legislation that adds to the annual federal deficit, even though Trump's plan could do so, according to some estimates .

—Reuters and CNBC's Jacob Pramuk contributed to this report.