Lanzini got the only goal of the game that day but the Argentine playmaker will not be fit to repeat his heroics this time around.
Without him West Ham lack a skilful creative spark in the middle of the pitch and it has been evident since the start of the season.
So could young Sead Haksabanovic - a low key signing from Swedish side Halmstads - be given the chance to fill Lanzini's boots against the North Londoners as something of a wildcard?
Sead Haksabanovic in action on his West Ham debut
The diminutive 18-year-old has a tricky name and the skills to match and impressed on his Hammers debut in the 3-0 win over Bolton in the Carabao Cup in midweek.
The Montenegro international clearly possesses the ability to hold his own in the English top flight but there will be question marks over his diminutive frame.
That did not hold Lanzini back, though, as West Ham fans have witnessed over the last two seasons.
For a central midfielder Haksabanovic knows where the goal is. From 46 games for Halmstads, the skilful playmaker has netted 10 goals by the age of 18 and plenty of assists along the way too. They are impressive stats for one so young and perhaps the reason West Ham have decided to take a chance on the youngster.
Lanzini is not expected to return until after the next international break so Haksabanovic could have announced himself at the perfect time.
If Bilic does roll the dice on Haksabanovic against Spurs it would be a sweet irony given the teenager reportedly supported Tottenham growing up in Sweden.