West Ham United's Manuel Lanzini celebrates the winner over Spurs
The Hammers go into the game on a high having beaten fierce rivals Tottenham Hotspur 1-0 last time out.
That win wrecked Spurs' title dreams, and the East Londoners could ruin Liverpool's own best laid plans of Champions League qualification with a victory at the Olympic Stadium.
Historically West Ham have lost to Liverpool - and neighbours Everton - more than other club.
But heading into the game a bold prediction Anfield legend Steven Gerrard made more than a year ago about West Ham and Bilic becoming bogeymen for Jurgen Klopp's Reds rings true.
West Ham were unbeaten in four games against Liverpool during Bilic's debut season last term and did the treble over Klopp's side with 3-0 and 2-0 wins in the league at Anfield and Upton Park respectively and a last gasp 2-1 victory in an FA Cup replay at the Boleyn Ground.
Liverpool manager Jurgen Klopp and West Ham boss Slaven Bilic
This season the Hammers were winning 2-1 at Anfield but were pegged back and settled for a 2-2 draw.
And Bilic will be hoping Gerrard's prediction stretches to a sixth meeting this weekend.
"They can be devastating on the counter-attack and Liverpool could be vulnerable because of how they like to press.
"I like Bilic and remember how tough his Croatia sides were to play against for England.
"He’s given them Croatian flair and they’ve been great to watch.
"I’d go as far as to say this is the best West Ham team I’ve seen."
Since then the Hammers have lost star man Dimitri Payet and their star has fallen somewhat this season.
But the win over Spurs proves they still possess that dangerous counter attacking flair, even without some of their key players.