Tottenham Hotspur are set to take on Swansea City at the Liberty Stadium tomorrow.
Tottenham are due to travel to the Liberty Stadium to face the relegation struggles.
Spurs arrive in Wales on the back of a 2-0 victory over Burnley, but the win did not come without a cost.
Harry Winks could miss the rest of the season with an injury that he picked up at Turf Moor, and there are also fears over Wanyama’s fitness.
The Kenyan midfielder had to be taken off against Burnley, and has not trained since the match.
But Pochettino believes that the powerful midfielder could be fit enough to play tomorrow evening.
"We need to assess him tomorrow. Today he wasn't on the pitch. We'll see,” Pochettino said.
"He will have a chance maybe to be in the squad but we need to assess him tomorrow.”
If Wanyama is fit, he is likely to start alongside Mousa Dembele in Tottenham’s midfield.
A Spurs victory against Swansea could see Pochettino’s side close the gap on league leaders Chelsea down to four points.