The Hammers have endured a torrid first half of the season, going out of the Europa League, the EFL Cup and then the FA Cup last time out off the back of a demoralising 5-0 defeat to Manchester City.
Slaven Bilic's second season in charge since taking over from new Eagles boss Sam Allardyce has been a far cry from his record-breaking first with the East Londoners sat in 13th place in the table at the halfway stage.
West Ham have - for whatever reason - struggled to adapt to life at their new Olympic Stadium home and go into the game off the back of three straight defeats in all competitions.
The long goodbye? Slaven Bilic with Dimitri Payet
And on the eve of the Palace game star man Dimitri Payet has effectively gone on strike and is refusing to play for the club as he seeks a move away.
Palace meanwhile are just one place and one point above the bottom three and are yet to win under Sam Allardyce, who will be desperate to get one over on his former club and close the gap between the two teams to just three points.
The abject performance last time out, players returning from injury, the African Nations and the issue surrounding Payet means Bilic must make sweeping changes to his side from that humbling defeat to City.
West Ham United's Darren Randolph in action
Randolph in for Adrian
Darren Randolph has now diposed Spaniard Adrian as West Ham's number one goalkeeper. Adrian was on duty for the City game and shipped five - not that he could do too much about any of the goals - and Randolph will come back in for the crunch Premier League tussle.
Oxford in for Nordtveit
Things can't get much worse for West Ham and now supporters are calling for some of the young stars to get a chance in the first team. Reece Oxford is certainly one of those and Bilic's favoured wingback system could suit him perfectly after he returned to full fitness following injury.
The teenager has said he is fit and ready on Twitter this week and he could replace what Cheikhou Kouyate was doing in the sweeper role as part of a back three - where he excelled playing in the Europa League earlier this season.
Nordtveit is not a defender and has, for most part, been woeful since signing on a free transfer in the summer.
Noble in for Fernandes
Many West Ham fans would like to see emerging young midfield talent Edimilson Fernandes remain in the side and argue he is a better player than Mark Noble.
But regardless of where you stand on the debate, one thing is for sure this is a crucial London derby and the Hammers need their homegrown captain on the pitch as the leader.
West Ham's Andy Carroll
Bilic has very limited options in the striking department right now and it may seem strange to suggest Andy Carroll should be left out for such an important game.
The big Geordie is coming up against centre backs who relish an aerial battle in the shape of former Hammers teammate James Tomkins and Scott Dann.
Bilic could be cunning and start young Ashley Fletcher who has impressed this season. His presence would give the Hammers pace and a willing runner in behind, which the Eagles defence would be far less comfortable facing.
Then after running the Palace defenders ragged for 60 minutes Bilic could introduce Carroll up against tiring legs, and we have all seen just how effective the big striker can be as an impact sub.
If anyone doubts just how urgently West Ham need reinforcements in the January window they need only look at West Ham's bench tomorrow which is sure to be filled with youngsters.
With Kouyate and Ayew away at the African Nations, Diafra Sakho out with injury until March, Simone Zaza's loan cut short and defenders Sam Byram and James Collins having only just returned for lengthy injuries the options are limited for the under pressure Croatian.
Here's how West Ham should line-up: