In the east versus south derby in the capital, The Hammers will look to arrest a run of three losses in a row in all competitions, without scoring in that period.
West Ham's Dimitri Payet looks dejected
Slaven Bilic is tasked in doing so without his mercurial Frenchman Dimitri Payet, who on Thursday was revealed to have told the Croatian he no longer wants to play for the club.
In the absence of the 29 year-old, West Ham have few options. Sofiane Feghouli set to leave the club for AS Roma, with Andre Ayew away on international duty with Ghana at the African Cup of Nations.
As Michail Antonio struggles with an illness also, Ashley Fletcher may get an opportunity to impress, as could Manuel Lanzini who has been a peripheral figure this term.
Swansea City's Fernando Llorente, Angel Rangel and Federico Fernandez celebrate after the game
On Allardyce's first return to East London with the Eagles, the former disgraced England boss is yet to win in his first four outings since taking the reins at Selhurst Park.
After losing to Angel Rangel's last minute winner at in South London 10 days ago, Palace roll into to Stratford sit just a point above Sunderland in 17th spot.
West Ham United's Manuel Lanzini celebrates scoring their first goal
The two sides have met 11 times in the Premier League's history, with Saturday's hosts unbeaten in their last three meetings with Crystal Palace.
When they met back in October, it was indeed Lanzini who scored the only goal of the game at Selhurst Park, where the ten-men of West Ham held out for a maximum haul.
As documented, Dimitri Payet is set to be omitted from the West Ham matchday squad - with Antonio also recovering from illness.
Cheikou Kouyate, like Ayew is at the African Cup of Nations, so Pedro Obiang is set to keep his place in midfield. Defender James Collins could return, however Diafra Sakho is still two months away with a back injury.
The trio of Gokhan Tore, Arthur Masuaka and Alvaro Arbeloa are long-term absentees also.
Here is how West Ham could line up:
Sam Allardyce is sweating over the fitness of several key men. Wayne Hennessey, Scott Dann, James McArthur and Christian Benteke are all doubts for the trip north across London.
Wilfried Zaha is on international duty, with new signing Jeff Schlupp primed to come straight into the starting XI. Forward Loic Remy could make his first start of the season, with Lee Chung-Young set for a rare opportunity.
Jonathan Benteke and Steve Mandanda are set to return at the end of the month, however Connor Wickham and Pape Souare are long-term absentees.
Here is how Crystal Palace could line up: