Two of English football's oldest rivals renew acquaintances at Goodison Park - here is all you need to know ahead of the match.
A Merseyside derby under the lights at Goodison Park is an intriguing final pre-Christmas fixture for the Premier League, with both rivals needing the points for different reasons.
Everton ended a five-match winless run with an excellent victory against Arsenal in midweek and will be hoping that a corner has been turned in their season; following it up with success over their cross-city neighbours would send the Toffees into the festive fixtures with a real spring in their step.
Jurgen Klopp's Reds got back on track with a comfortable 3-0 victory at Middlesbrough on Wednesday, but they could start this fixture nine points behind Chelsea if the league leaders win on Saturday. The pressure will be on Liverpool to take three points away from Goodison Park, something they have not done since 2011.
Everton's Ashley Williams celebrates scoring against Arsenal
The Key Battle - Romelu Lukaku vs Dejan Lovren
The big Belgian has scored three times in this fixture already for Everton, and will be striving to add to that tally on Monday evening.
Lovren has been generally solid for Liverpool this season but still makes occasional costly errors; Reds supporters will be hoping he manages to steer clear of any such mistakes in the derby.
Everton's Romelu Lukaku in action with Liverpool's Dejan Lovren
Liverpool cruised to a 4-0 win in April's meeting at Anfield, which was one of the final nails in Roberto Martinez's Everton coffin.
The last four Merseyside derbies at Goodison have ended with the spoils shared, including last season's 1-1 draw.
Liverpool's Adam Lallana in action with Everton's James McCarthy
Recent form – most recent last:
Everton - LDLDLW
Liverpool - WDWLDW
Who’s the ref?
Mike Dean will be keeping control of affairs in this one.
It is the first time he has taken charge of Everton or Liverpool in over a decade, and his first taste of overseeing a Merseyside derby.
What time is kick off?
The action begins at 8pm.
Where can I watch it?
Everton v Liverpool is live on Sky Sports 1, with coverage starting at 7pm.
Everton - 3/1
Draw - 11/4
Liverpool - 17/20