The Gunners can return to the top of the table with a win at Goodison Park.
Everton have had a perfectly symmetrical opening to their Premier League campaign. The Toffees first 15 games have included five wins, five draws and five defeats as well as 19 goals scored and the same number conceded.
Their recent slip is cause for concern, however. Ronald Koeman's side have won just once in their last 10 league matches and have slipped from looking like potential top four contenders in September to scrapping to stay in the top half by Christmas.
Looking to take advantage of an out of sorts home side are Arsenal, who will return to the Premier League's summit - until tomorrow evening at least - with a victory on Merseyside.
The Gunners have won their last three matches and are protecting a good record at Goodison; they have lost just once there in nine visits.
Arsenal's Alexis Sanchez celebrates scoring their second goal
The Key Battle - Ashley Williams vs Alexis Sanchez
The Welsh skipper has not yet provided the solution to Everton's defensive problems and is struggling to convince supporters that his signing was a wise one; a strong performance against Arsenal's in-form Chilean maestro could give his Toffees career a much-needed kickstart.
Everton's Ashley Williams makes a clearance
First-half goals from Danny Welbeck and Alex Iwobi secured all three points for Arsenal in March's meeting on Merseyside, with the young Nigerian finding the net for the first time in a Gunners shirt.
Recent league form – most recent last:
Everton - WLDLDL
Arsenal - WDDWWW
Who’s the ref?
Mark Clattenburg takes charge of his second game in three days, following on from overseeing Liverpool's draw with West Ham on Sunday.
The experienced official has shown 61 yellow cards and two reds in his 16 games to date this season.
Referee Mark Clattenburg (L)
What time is kick off?
The match starts at 7.45pm.
Where can I watch it?
Everton v Arsenal is live on BT Sport 1, with build-up beginning at 7pm.
For those on the move, live radio commentary is available on BBC 5Live.
Everton - 3/1
Draw - 11/4
Arsenal - 10/11