Newcastle went into Saturday's visit of Birmingham on the back of two successive defeats which slightly derailed their automatic promotion bid.
But Rafael Benitez's side responded by thrashing the Blues 4-0 in a victory which saw Dwight Gayle grab a hat-trick, reaching 17 league goals in 16 outings.
The Latics, on the other hand, are not in the best of form - particularly at The DW Stadium - and Prutton believes the Magpies will build on their morale-boosting win over City this past weekened.
"Newcastle are flying while things are getting tougher for Wigan, who haven't scored in their last four home league games," he told Sky Sports.
"That could be five after this one as Newcastle are so solid on the road. They've won 22 points away this season - a joint-high away points haul in the top four divisions with Scunthorpe - and conceded just five goals on the road."
Newcastle are only one point clear of second-placed Brighton and the Spanish manager will hope to see Albion slip up away to Blackburn tonight.
Benitez's side, as they proved in recent weeks, are not going to walk back into the Premier League. It'll be a very long and very hard road, but they should, in theory, have enough to move one step closer by beating Wigan tonight.
When you have a striker like Gayle, it is very difficult to stop a team like that.