The Frenchman put in an enthusiastic cameo off the bench for Spurs.
It was a fairly unremarkable game which could have easily gone either way but Spurs fans were left frustrated for their long trip back to London.
Tottenham's Moussa Sissoko in action with Manchester United's Matteo Darmian
With the game going away from them Spurs boss Mauricio Pochettino threw Frenchman Moussa Sissoko into proceedings – with the hope he could turn the game on its head.
In fairness to the midfielder, signed for big money from Newcastle United in the summer, he did put in a rather impressive performance – although could not have a telling impact on proceedings.
Manchester United's Paul Pogba celebrates after the game as Tottenham's Moussa Sissoko looks dejected
Speaking after the game to the official Tottenham Hotspur website he spoke about the impact he tried to have on the game from the bench:
“We have to analyse where it went wrong and focus on Wednesday and back to back home games.
"I came on and tried to give us some energy. I gave my best but unfortunately it wasn't enough to get a point."
Sissoko has not been universally popular since making his move to Spurs in the summer and needs a big performance soon if he is to start winning over the Tottenham fans.
This cameo is hardly going to achieve that, but hopefully he can soon start to find his best form for Spurs.