Tottenham midfielder had been a big part of their early season success.
The Kenyan was part of the Spurs side which lost 1-0 to Manchester United on Sunday, and missed a golden opportunity to equalise early in the second half.
Tottenham's Victor Wanyama in action with Manchester United's Zlatan Ibrahimovic
It was a miss which it is hard to imagine Eric Dier making, with the England international once again left on the bench to accommodate Wanyama.
Dier being regularly overlooked in midfield has been swept to one side due to the fact he has had to fill in to cope with injuries in defence, but with Tottenham's backline now healthy, Mauricio Pochettino's decision to select Wanyama comes closer under the microscope.
Wanyama is a favourite of Pochettino, who managed him at Southampton, and the midfielder has lived up to expectation so far with a string of solid displays.
Yet this is a Tottenham team which are sorely lacking the creativity and composure they had last season, with the midfield trio of Dembele, Alli and Dier among the best in the Premier League.
Tottenham's Dele Alli celebrates scoring their first goal with Eric Dier
This campaign Alli has been inconsistent, perhaps missing close pal Dier playing alongside him, while whichever of Harry Kane or Vincent Janssen has started up front have looked far too isolated.
Wanyama is not essentially a problem for Spurs, but he is offering less of a solution than Eric Dier could.
With 20 starts in all competitions this season, it may be time to take the Kenyan out of the side, put Dier in, and see if it helps Tottenham get back on track, beginning with this week's home fixture against struggling Hull City.