Arsenal make their first trip to the London Stadium on Saturday evening; here is all you need to know ahead of the match.
West Ham are still limping their way through their debut season in their new home.
They have won just twice in six Premier League matches there and average just a goal a game, and that combined with their poor away form means they go into the weekend just a point above the bottom three.
Arsenal, meanwhile, have not lost a game since the opening day and sit in fourth just three points off the top of the table.
Last weekend's win over Bournemouth saw them climb four points clear of rivals Tottenham, and the Gunners go into this game protecting the only remaining unbeaten away record in the Premier League.
Arsenal's Theo Walcott in action with Bournemouth's Nathan Ake
The Key Battle - Theo Walcott vs Aaron Cresswell
Walcott's strike against Bournemouth last time out took his season's tally to nine in all competitions, and he will be looking to reach double figures this weekend.
It will be a tough test for Hammers left-back Cresswell, who was taken off injured as a precaution in the midweek EFL Cup thumping at Old Trafford but should be fit to start on Saturday.
West Ham's Aaron Cresswell in action with Crystal Palace's James McArthur
April's battle between these two sides resulted in a six-goal thriller.
Arsenal saw a two goal lead overturned by a quickfire Andy Carroll hat-trick before Laurent Koscielny's equaliser spared their blushes and ensured the visitors left with a point.
Recent league form – most recent last:
West Ham - WWLDLD
Arsenal - WDWDDW
Arsenal's David Ospina and Shkodran Mustafi celebrate after the game
Who’s the ref?
Craig Pawson will be in charge at the London Stadium.
The only red card he has shown in his 12 games this season was at the home of the Hammers, with Bournemouth's Harry Arter given his marching orders during West Ham's 1-0 win in August.
Referee Craig Pawson (L)
What time is kick off?
Saturday's match starts at 5.30pm.
Where can I watch it?
BT Sport 1 are showing West Ham v Arsenal, with coverage getting underway at 5pm.
West Ham - 100/30
Draw - 29/10
Arsenal - 3/4