The Reds beat Sunderland 2-0 at Anfield on Saturday afternoon to continue their superb Premier League form, but Jurgen Klopp's focus will be on the EFL Cup this evening.
With a trip to Bournemouth coming up this weekend, Klopp has chosen to rest a number of players, with Simon Mignolet coming in for Loris Karius in goal.
Trent Alexander-Arnold, Lucas Leiva, Ragnar Klavan and Alberto Moreno form a completely revamped back four, whilst Kevin Stewart will sit in front of the back four, with Emre Can and Georginio Wijnaldum ahead of him.
It appears to be a diamond system for Klopp tonight, with Ovie Ejaria behind a front two of Sadio Mane and Divock Origi, who may end up playing as wide forwards tonight.
The bench features first-team regulars like Dejan Lovren, Nathaniel Clyne, James Milner and Jordan Henderson, as well as youngsters Marko Grujic and Ben Woodburn.
Meanwhile, Leeds enter the game having beaten Rotherham United on Saturday evening, and Garry Monk will be keen to give Liverpool a real battle at Anfield tonight.
He has though made a change in goal, as Robert Green has been left out in favour of Marco Silvestri, as has been the norm for Leeds during their EFL Cup campaign.
Gaetano Berardi comes in for Luke Ayling at right back, with Liam Cooper and Kyle Bartley continuing at centre back, as Pontus Jansson is out of the squad for tonight's game.
Ronaldo Vieira and Eunan O'Kane start in central midfield, with Hadi Sacko and Stuart Dallas out wide, and Kemar Roofe supporting lone striker Souleymane Doukara, as Chris Wood has been left on the bench.
Wood is joined by Green and Ayling as well as Matt Grimes, Kalvin Phillips, Alex Mowatt and Marcus Antonsson as Leeds chase a cup upset at Anfield this evening.
- Simon Mignolet
- Ragnar Klavan
- Alberto Moreno
- Trent Alexander-Arnold
- Emre Can
- Ovie Ejaria
- Lucas Leiva
- Kevin Stewart
- Georginio Wijnaldum
- Sadio Mané
- Divock Origi
Substitutes: Benjamin Woodburn, Loris Karius, Nathaniel Clyne, Dejan Lovren, Marko Grujić, Jordan Henderson, James Milner.
- Marco Silvestri
- Kyle Bartley
- Gaetano Berardi
- Liam Cooper
- Charlie Taylor
- Stuart Dallas
- Eunan O'Kane
- Hadi Sacko
- Ronaldo Vieira
- Souleymane Doukara
- Kemar Roofe
Substitutes: Robert Green, Luke Ayling, Matt Grimes, Alex Mowatt, Kalvin Phillips, Marcus Antonsson, Chris Wood.