Spurs travel to Stamford Bridge in the day's late kick-off having fallen four points and four places behind their London rivals.
That has come as a result of a poor run of form from the team who looked so assured in the early weeks of the season. Spurs have won just one of their last nine in all competitions, and crashed out of the Champions League this week.
Chelsea, in contrast, have won their last six league games in a row without conceding a single goal across that run, form which has propelled them to the top of the Premier League table.
The wise bet looks to be on the hosts to make it seven in a row, but former Blues star and assistant boss Wilkins believes Spurs have a chance.
Wilkins wrote: "I do think there could be a way for Spurs to get at Chelsea this Saturday. The vulnerable men in the 3-4-3 are the two wider centre-backs, Cesar Azpilicueta and Gary Cahill, and the way to play against that system is with two strikers.
"Spurs need to drag them out into the wider areas and try to get in behind them. Cahill is not a left-back and he does not want to have to go out there. He is the man that Spurs should try to target.
"That is why I think Spurs’ most important player could be Son Heung-min. I know he had a difficult night in Monaco on Tuesday but he makes fantastic runs into the channels and has genuine pace. If he run into that left-back area, between Cahill and left wing-back Marcos Alonso, that probably represents Spurs’ best chance."
It is certainly interesting of Wilkins to suggest that Chelsea's 3-4-3 formation could prove a weakness; it has been infallible in recent weeks.
The Blues' winning included 4-0 and 5-0 thrashings of Manchester United and Everton respectively, and if Spurs can pull off a win at the Bridge it will arguably be one of the results of the season so far.