Holloway returned to the Loftus Road job after 10 years earlier this month, and got his second reign off to a perfect start with a 2-1 home victory over Norwich City last weekend.
This weekend his side travel to face Ipswich, who are struggling under Mick McCarthy in recent weeks.
However, former midfielder Prutton is anticipating an improved Ipswich side at Portman Road on Saturday, and believes Holloway will have to settle for taking a single point back to London.
Prutton wrote for Sky Sports: "With Ollie going in, they had a fantastic start, albeit with a massive helping hand from Martin Olsson.
"Ipswich just didn't turn up live on Sky against Forest last weekend, losing 2-0. It sounds like the Ipswich fans are getting a bit restless.
"Mick McCarthy would have been drilling into his team all week the importance of starting well in this one. What I think we'll see is that new manager bounce against a current manager giving his team a kick up the backside, so I'm going for a score draw."
A feel-good start under a new manager is all about momentum, and so whilst Ho0lloway and Rs fans will of course be hoping for a win, a draw may not be too bad a result in East Anglia.
QPR have lost just two of their last nine Championship games, and avoiding defeat again would maintain the solid foundations of Holloway's new reign.