Jose Mourinho's side welcome the Turkish side to Old Trafford for the first time since a famous night in 2004.
Manchester United manager Jose Mourinho
After a drab goalless draw at Anfield on Monday evening, Manchester United face Fenerbahce on Thursday evening knowing that a defeat will leave them with plenty of work to do if they are to qualify for the Europa League knockout rounds.
Jose Mourinho's side are currently third behind Feyenoord and table toppers Fenerbache after the opening two Group A fixtures, and supporters will be hoping for slightly more in the way of attacking adventure following Monday evening's more cautious display.
Manchester United's Zlatan Ibrahimovic looks dejected after a missed chance
The Key Battle - Zlatan Ibrahimovic vs Martin Skrtel
Ibrahimovic has been off the boil by his high standards of late; he was quiet at Anfield and the Swede's winner against Zorya last time out in the Europa League is his only goal in his last seven games.
Former Liverpool man Skrtel returns to England to try and nullify Ibrahimovic in what is sure to be a physical battle.
Former Liverpool man Martin Skrtel returns with Fenerbahce
These two teams were drawn against each other in the group stages of the 2004/05 Champions League, and the encounter at Old Trafford was a special occasion for a certain Wayne Rooney.
Making his debut for United following his summer move from Everton, Rooney hit a sublime hat-trick in a 6-2 win for the hosts. The return fixture was less impressive, as Sir Alex Ferguson's men went down to a 3-0 defeat in Istanbul courtesy of a Tuncay treble.
Recent form – most recent last:
Manchester United - LWWWDD
Fenerbahce - DWWWDD
Who’s the ref?
Benoit Bastien is the man in the middle for this one. In his eight games across domestic and European competitions so far this season, the Frenchman has brandished 34 yellow cards and one red.
Manchester United's Paul Pogba
What time is kick off?
The action at Old Trafford starts at 8.05pm
Where can I watch it?
BT Sport 2 is the place to see this one, with coverage beginning at 7.30pm.
Manchester United - 3/5
Draw - 3/1
Fenerbahce - 5/1