The Magpies head to Oakwell in search of their fourth consecutive win.
Having coasted to victory against Brentford on Saturday, Newcastle's next task is an away trip to Barnsley.
The Magpies have won three games on the bounce now and have moved up to second in the table, just a point behind leaders Norwich.
Their opponents on Tuesday suffered a 4-2 defeat to Fulham on Saturday, and will be unable to call upon the services of Adam Armstrong, who is on loan from Newcastle.
As Rafael Benitez looks to continue his side's impressive form, could this be the team he selects at Oakwell?
Karl Darlow will retain his place in goal as he continues to keep Matz Sels out of the team, and the 26-year-old could have the same back four in front of him as Saturday.
Jamaal Lascelles was withdrawn after an hour at St James' Park, but Benitez has confirmed his captain will be okay for the trip to Barnsley. Vurnon Anita's performance against Brentford could force DeAndre Yedlin to watch from the bench again.
Yoann Barbet of Brentford (L) and Deandre Yedlin of Newcastle United in action
Matt Ritchie missed Saturday's victory due to sickness, but the Scotland international is available for Tuesday night, and should start in place of the man who replaced him, Christian Atsu. The Ghanaian has been sensational in Ritchie's absence, but his lack of match fitness could see the summer signing from Bournemouth replace him in the starting XI.
Yoan Gouffran's work rate makes him the ideal choice to play out wide in away games, with Newcastle having to grind out results on the road on more than one occasion this season.
Dwight Gayle celebrates with Jonjo Shelvey after scoring the third goal for Newcastle United
Isaac Hayden is in contention to swap places with Jack Colback, with Benitez happy to chop and change his central midfielders, although Jonjo Shelvey will almost certainly start after another fantastic performance against Brentford.
While Mo Diame has been less than impressive in black and white this season, Benitez will likely want to go with another midfielder rather than the more offensive Ayoze Perez away from home, meaning the former Hull man could come back into the side.
Up top surely has to be the in-form Dwight Gayle, who bagged another two goals in the win against the Bees, making it nine goals so far this season for the Newcastle number nine.
Dwight Gayle celebrates scoring the third goal for Newcastle United