Sunderland take on Middlesbrough for the first time in the Premier League since 2009.
The Wear-Tees derby will be David Moyes' first home game in charge of the Black Cats, who started life as Sunderland manager with a 2-1 defeat to Manchester City.
Despite the result, the Scot will have been pleased by his team's performance, who were arguably unlucky to come away from the Etihad Stadium with no points.
Since the opening day, Sunderland have only brought in one more player, with Steven Pienaar reuniting with his old Everton boss. With more injuries and possible departures, could this be the team Moyes puts out against Aitor Karanka's Middlesbrough side?
Sunderland will have to field a totally new centre-back partnership on Sunday, with Lamine Kone ruled out with a back injury, and Younes Kaboul on the brink of completing a move to Watford.
With Sunderland now without their best defensive pair, the door opens for Papy Djilobodji to make his debut in red and white, and he could be partnered with John O'Shea, who started in midfield against Manchester City.
New signing Paddy McNair has stated that he sees his future as a central midfielder, and that is where he could be deployed with O'Shea dropping in to defence. Alternatively, those two could swap, but O'Shea's experience could be better off used against Middlesbrough's target man Alvaro Negredo.
Lynden Gooch made his debut last week, and his performance in Manchester should be enough to see him retain his place in the starting XI.
Despite a depleted squad, the one area in which Sunderland are blessed with options is out wide, which could put Duncan Watmore's position under threat. The youngster did little to impress last time out, and should be seen more as an impact substitute at this stage.
That could open the door to either Adnan Januzaj or Wahbi Khazri. The Tunisian playmaker may have the edge over his Belgian teammate due to his defensive capabilities, with Moyes wanting to keep his team solid.
As usual, up top will be Jermain Defoe, who opened up his account for the season and will be hoping to add to it in his first taste of the Wear-Tees derby.