Kone has sustained a back injury and will not feature in Sunday's Wear-Tees derby.
Manchester City's Sergio Aguero in action with Sunderland's Lamine Kone
Lamine Kone's future at Sunderland may be unclear, but what is certain is that he will not feature for the club in their derby match against Middlesbrough after reportedly picking up a back injury during training.
Kone did play in the Black Cats' 2-1 defeat at Manchester City last weekend and has been angling for an improved contract at the club despite only signing in January.
The injury news was confirmed by Sunderland boss David Moyes in Friday's press conference as he now assesses his defensive options for what will be the first Premier League fixture between Sunderland and Middlesbrough since the latter's relegation in 2009.
Lamine Kone celebrates scoring the third goal for Sunderland with Younes Kaboul and Jermain Defoe
So who will replace the Ivory Coast international for what is arguably one of Sunderland's most anticipated fixtures this season?
Moyes may be reluctant to select Paddy McNair after his new signing had a debut to forget last weekend after coming on as a substitute only to score a late own goal that denied his team of a valuable point.
Veteran defender John O'Shea was pushed forward into midfield last weekend and may do the same again on Sunday but is still more than capable of lining up alongside Younes Kaboul in the centre of defence if needed.
Sunderland's John O'Shea in action with Manchester City's Fabian Delph
However, another new addition in Papy Djilobodji, who signed for £8m from Chelsea, could well fill in at centre-back for Kone and Moyes has confirmed that the Senegal international will feature at some point during Sunday's game.
Djilobodji was an unused substitute at the Etihad but now could be thrown straight into the starting line-up in what will be one of the most heated and important matches for both Sunderland and Middlesbrough this season.
So who will win the Wear-Tees derby?
Chelsea defender Papy Djilobodji during a loan spell at Werder Bremen