HITC Sport looks at five things worth keeping an eye on in the Premier League this weekend.
Could Leicester inflict more trouble for Wenger?
Both clubs endured opening-day defeats last weekend so the need for points for both sides is important. For Arsenal the pressure is mounting day by day. Much was made of Arsenal's defensive problems after the defeat to Liverpool with Rob Holding and Calum Chambers at the heart of the back line.
Large sections of Arsenal fans have already become restless with the club's relative lack of transfer activity. Jamie Vardy and Riyad Mahrez, two players who Wenger wanted the club to sign, have committed their futures to Leicester City, and a decisive contribution from either of those will further the frustrations of many.
Meanwhile, this will be new territory for the defending champions Leicester. Nobody will expect the Foxes to repeat what was done last season, and a loss tomorrow for the hosts will mean back-to-back defeats, something they did not experience in the entirety of last term, and which would raise questions as to whether there is a title hangover.
The Gunners beat the champions twice last season including a 5-2 victory at the King Power Stadium. A defeat would spark more uproar in the North London. Of course both sides need the points, but given the predicament Wenger finds himself under, a defeat will surely be a huge blow.
Arsenal manager Arsene Wenger looks dejected
Conte and Mazzarri renew their rivalry
Chelsea and Watford played out draws in the two meetings at Stamford Bridge and Vicarage Road last season and it's set to be enough tight encounter with two new managers in the dugout.
However, there seems to be a rivalry between the two Italian managers. When Mazzarri was at Napoli and Conte at Juve, any chance of a friendly relationship was diminished with the now-Watford manager accusing Conte of copying his tactics, referring to his three-at-the-back formation. The pair also failed to shake hands after the 1-1 draw in Naples in 2013.
Chelsea manager Antonio Conte
Can Guardiola play around Stoke?
The Spaniard has played and managed in some of the most intimating places in European football, but his first Premier League away game with Manchester City will be a fierce introduction to life on the road in England.
He has been able to change the identities of the likes of Barcelona and Bayern Munich, but the task to do it at City will be arguably his toughest yet. The Premier League is different to La Liga and Bundesliga, not just in terms of its style of play and intensity but also with teams outside top six increasingly going toe-to-toe with any side in the league.
Mark Hughes' Stoke side are not the cliched Tony Pulis team of old, and if any side is not on their game they can get punished, ask City players from last season. Guardiola encourages his players to play to a high level of performance with consistency every game, but will they be able to do it at the Britannia?
Manchester City manager Pep Guardiola
Williams can be a key man for Koeman
The sale of John Stones would have been a disappointment for any Evertonian. Seeing a young British talent leave would have been a blow, but they have certainly replaced him with a man who will fit perfectly.
The club's frailties at the back were evident last year. Stones looked suspect in the second half of last term while Funes Mori was still coming to terms with the demands of the league. Williams' know-how, leadership and experience will give some reassurance at the back, and the defender arguably arrives at the peak of his powers after impressing in France this summer.
West Ham start new life in Stratford
Moving to a new home is always set to be difficult and football clubs are no different. You only have to remember Arsenal's initial struggles when they moved to the Emirates, as they drew back-to-back home games against beatable opposition in Aston Villa and Middlesbrough.
It will take time for the Hammers to make the London Stadium their home; Upton Park was synonymous with West Ham United, so the transition will take a while. Slaven Bilic's men have already won in Stratford, winning their Europa League tie, so that will help the players and supporters bed into the new ground.
West Ham's Olympic Stadium v Domizale